Regina George was born and raised by her rich parents, she grew up to evolve as the queen bee that knew how to control everybody around her, as later seen in the movie, Cady Heron becomes a second clone of Regina. Regina's sense of control, manipulation and superiority grew as a result of the way her mother, Mrs. George raised her, trying to be a "cool mom" letting her daughter loose.
In 8th grade, Regina George refused to invite Janis Ian to her birthday, which was an all-girl pool party, because she accused her of being a lesbian. "So then in eighth grade, I started going out with my first boyfriend Kyle who was totally gorgeous but then he moved to Indiana, and Janis was like, weirdly jealous of him. Like, if I would blow her off to hang out with Kyle, she'd be like, "Why didn't you call me back?" And I'd be like, "Why are you so obsessed with me?" So then, for my birthday party, which was an all-girls pool party, I was like, "Janis, I can't invite you, because I think you're a lesbian.""
Regina is followed by her "Other two" who are "just her little workers," Karen Smith and Gretchen Wieners. The special ingredient behind Regina's control was two things, sex appeal, and the insecurity of others. Where Regina only had followers because she mastered making girls feel inferior next to her for her attractiveness, and used guys to feel superior out of their attention. For example, Shane Oman and Aaron Samuels, both used as Regina's toys. "She's evil, but she's fabulous." quoted by Damian.
Relationship with Cady HeronEditCady Heron was in Regina's eyes, "so lucky to have Regina," guide her away from social suicide. Regina and Cady start to become close friends at the start of the movie, ever since Regina invites Cady to the table of The Plastics. Regina invited Cady to the table, after saving her from Jason, a Skeez. Regina did not know her, but she thought she was really pretty, to which Cady agreed. Janis and Damian had previously informed Cady that she was a "regulation hottie" and a "little slice." Regina decides to make Cady one of the plastics, so that Cady could be under her control and hopefully Cady would not become competition (or hurt Regina's popularity status in any other way).
Cady develops a crush on Aaron Samuels, then tells Gretchen and Karen about it. Cady didn't know Aaron was Regina's ex-boyfriend. Gretchen informed Cady that made him off-limits, then said she would never tell Regina. It would be their little secret, for the rest of the afternoon. Regina called Cady and said that Gretchen told her Cady's little secret. Regina said it was okay. A month later at Chris Eisel's Halloween Party it was Cady's chance to start dating Aaron. Right in front of Cady, Regina took Aaron back. This set Cady off enough to go along with a plan from Janis Ian to sabotage Regina's life.
Cady provided Kälteen Bars to Regina to ruin Regina's technically good physique. Cady and Damian tried to have Aaron find Regina cheating with Shane Oman, in the projection room above the auditorium, but was not successful. Eventually, Word Vomit got the best of Cady and she told Aaron that Regina was cheating on him. Aaron broke-up with Regina saying because of this, though he said some guy on the baseball team told him. Regina was not allowed to sit with the Plastics, once sweatpants became all that would fit her.Cady became the new Queen Bee. Gretchen and Karen pry Cady into having a small get-together. Cady tried to seduce Aaron, but threw-up on him. Regina saw this. Janis informs Cady that she was no longer innocent, but plastic. Later was told the truth about Kälteen Bars by Shane Oman. At this point Regina knew Cady sabotaging her and decided to take-down the remaining three Plastics. Regina adds herself to the Burn Book, as well as every girl not previously mentioned other than Cady, Gretchen, and Karen. Regina brings the book to Mr. Duvall claiming she found it in the bathroom. She also publishes many pages from the Burn Book and distributes them throughout the school. Regina's plan worked the school erupted in chaos. A workshop began in the gymnasium for all Junior girls. Janis Ian apologized to Regina for sabotaging her with the secret help of Cady. Regina stormed out of the building Cady caught up to her, then Regina was hit by a bus.
"Get in loser, we're going shopping."
"But you're like really pretty."
"Oh my God, I love your skirt! Where did you get it?"
"I gave him everything! I was half a virgin when I met him."
"Boo, you whore."
"I love her. She's like a Martian!"
"Gretchen, stop trying to make fetch happen! It's not going to happen!"